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In transgenic mice, tau antisense oligonucleotides (AS0) reduced the amount of tau mRNA by 50% and showed inhibition of neuronal loss, hippocampal atrophy, and neuronal loss ( Discussion Post-COVID complications pose a significant public health burden, with a recent study from CDC reporting its prevalence at between 20 and 25% among COVID-19 patients ( The extensive literature review above revealed the tau deposits in the brain by examining the tissue samples from autopsies of COVID-19 patients compared to controls